![]() Results obtained with isolated human islets. COMSOL Multiphysics Volume 1: A Graphical Instructional Guide (Comsol Multiphysics Modeling with Minimum Text) at. Secretion calculated by the model was in good agree- ment with the experimental Informative assessment of islet quality and function. Of glucose, oxygen, or other compounds of interest, and can provide an Studies allow the quantitative assessment of insulin release kinetics underįully controllable experimental conditions of varying external concentrations Procedures are compared to those calculated by the model. ![]() Insulin release (GSIR) perifusion studies performed by us following standard Here,Įxperimental results obtained from two different dynamic glucose-stimulated Transplanted, or encapsulated islets in response to various glucose profiles. Model of insulin secretion in avascular pancreatic islets that can be used toĬalculate insulin secretion for arbitrary geometries of cultured, perifused, We have recentlyĭeveloped a general, local concentrations-based multiphysics computational This module also has interfaces for circuit modeling, a SPICE interface, and support for importing ECAD drawings. Improved artificial or bioartificial pancreas devices. Using the multiphysics capabilities of COMSOL Multiphysics you can couple simulations with heat transfer, structural mechanics, fluid-flow formulations, and other physical phenomena. Our understanding of the processes involved, but also to allow betterĪssessment of β -cell function in diabetic patients or islet transplant recipients as well as the development of Glucose-stimulated insulin secretion is of obvious interest not only to improve Regulator of glucose levels, the quantitative modeling of their Journal of Biomedical Science and Engineering,ĪBSTRACT: Because insulin released by the β-cells of pancreatic islets is the main CechinĬOMSOL Multiphysics Diabetes Mellitus FEM Model Glucose-Insulin Dynamics Hill Equation Islet Perifusion Islets of Langerhans Glucose-stimulated insulin secretion in isolated pancreatic islets: Multiphysics FEM model calculations compared to results of perifusion experiments with human isletsĪUTHORS: Peter Buchwald, Sirlene R. This series of models demonstrates how to do advanced electric machine modeling with COMSOL Multiphysics® in 2D, 2.5D, and full 3D with end effects included. Comsol, AB (2007) COMSOL multiphysics modeling guide, version 3.4.
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